A Master’s thesis in the Department of Life Sciences, College of Science, University of Kerbala, presented by Fatima Adnan Hussein, investigated the impact of genetic polymorphism of certain biomarkers on the severity of diabetic foot ulcers, comparing diabetic patients with and without ulcers.

The study included 100 patients, analyzing demographic factors, isolating and identifying ulcer-associated bacteria, examining genetic polymorphism in MCP-1 and CRP genes, and measuring fibrinogen levels in the blood.

The results revealed that demographic factors significantly influenced ulcer development, while specific bacterial strains were identified as contributors to ulcer complications. Additionally, elevated fibrinogen levels were observed in patients with ulcers, indicating active inflammation.

The study recommended further research on ulcer-causing bacteria and the role of genes related to insulin sensitivity, emphasizing fibrinogen measurement as a potential tool for monitoring ulcer progression and treatment.