The College of Science at the University of Kerbala discussed the PhD dissertation of Riham Hussein Noor from the Department of Biology, which focused on evaluating physiological markers and gene expression of COX-2 and IL-23 in women with abnormal uterine bleeding.

The dissertation aimed to clarify the relationship between certain physiological and genetic indicators in affected women by studying 60 patient cases compared with 30 healthy women as a control group.

The findings revealed elevated levels of IL-23 and COX-2, along with disruptions in some sex hormones, while molecular analysis showed a clear increase only in COX-2 expression. This suggests that the disease is associated with hormonal imbalance and inflammatory response, with COX-2 potentially serving as a molecular marker for diagnosis.

The study concluded that increased COX-2 levels and hormonal disturbances represent significant indicators of the disease, whereas IL-23 did not show statistically significant differences, reducing its role in this group of patients.

The dissertation recommended monitoring COX-2 and hormone levels to facilitate diagnosis and expanding future research on treatments targeting inflammation and hormonal imbalance to improve patient outcomes.