A doctoral thesis at the College of Science at the University of Karbala discussed the synthesis and biological activity of some new derivatives of 2-amino benzothiazole.

The study, presented by the student Noor Al-Huda Mohammed Abdul-Hussein from the Department of Chemistry, aimed to prepare new benzothiazole derivatives containing thiazolidinone, quinazolinone, and chalcone units and diagnose them using established spectroscopic analysis methods. Additionally, it examined all newly prepared compounds to confirm their antioxidant and antibacterial activities.

The study included the preparation of some thiazolidinone and quinazolinone derivatives using microwave technology. The chalcones were manufactured by Claisen-Schmidt condensation, which are important intermediates introduced into several reactions to obtain important heterocyclic compounds. DPPH was used to determine the antioxidant activity of the newly produced compounds.

The study concluded that most of the compounds exhibited strong radical scavenging properties against DPPH, particularly surpassing ascorbic acid. In terms of their activity against bacteria, some of the prepared compounds were found to be more effective than gentamicin against S. aureus and E. coli.

The study recommended conducting extensive investigations to determine the minimum affected concentration and toxicity of the new prepared compounds, as well as studying the biological effects of these compounds on various types of bacteria, fungi, viruses, and diseases affecting animal tissues.