A master’s thesis at the College of Science, University of Kerbala, explored the molecular characterization of virulence factors in Pseudomonas aeruginosa isolated from patients with ear infections in Karbala.

The study, conducted by Zina Haider Abbas from the Department of Biology, aimed to investigate bacterial resistance to antibiotics and its relationship with virulence factors such as biofilms and efflux pumps. It also included predicting the three-dimensional structures of drug targets using bioinformatics tools.

The findings revealed a high prevalence of microbial ear infections, with Pseudomonas aeruginosa being the most common and resistant to most antibiotics except colistin. The study highlighted adenylate kinase as a promising target for future therapeutic approaches.

The study recommended monitoring the spread of these infections, analyzing resistance genes, and developing innovative treatments using nanotechnology and alternative medicine.